As a form of sensibilization, chemotherapeutic drugs used for CRC treatment, such as 5-fluorouracil and doxorubicin, have been used in CSCs from CRC cell lines in combination with autologous Vγ9Vδ2 T cells, increasing DR5 expression and improving cytotoxic activity at low doses [53]. This evidence concerns the gene TNFRSF10B and colorectal carcinoma.