Another facet of atherosclerosis pathogenesis is the upregulation and activation of TLR4 and NLRP3 inflammasome and the nuclear transcription factor NF-kB as an extension of the endogenous host response to cholesterol efflux signaling misregulation, which is mediated by oxLDL and CCs [33,54,105,108,109]. The gene discussed is NFKB1; the disease is atherosclerosis.