Several cell adhesion molecules (VLA-4 and VLA-5, for instance), soluble factors (such as IL-6) and extracellular matrix components (for example, fibronectin) have been shown to be relevant during BM-ME and MM cell interactions and responsible for MM cell survival and importantly, for the so-called cell adhesion-mediated drug resistance (CAM-DR) [13,14,15,16]. Here, ITGA5 is linked to Miyoshi myopathy.