CASC3 and Miyoshi myopathy: These results were equivalent to the experiments in which BM-MSC were first pre-treated with the PKC and NF-κB inhibitors, suggesting that in a more real and physiological context, the treatment with these compounds is also effective in inducing susceptibility to BTZ, and they did so, by synergistically inhibiting the supportive signals given by BM-MSC and by directly having a cytotoxic effect on MM cells.