The anti-tumor activity of senescent cells is articulated on different types of interventions: recruitment of immune cells that can be decisive by exerting a strong and specific anti-tumor activity for tumor regression; secretion of thrombospondin 1 which prevents the senescent tumor cells to exit the state of senescence; clearance of pre-malignant cells pushed into cell senescence state that can be eradicated by immune cells recruited by some components of the SASP [21,151]. This evidence concerns the gene THBS1 and neoplasm.