Many of the anticancer activities of flavonoids and other polyphenolics resemble those reported for CDIM/NR4A1/2 antagonists and like the antagonists, the flavonoids quercetin and kaempferol also bound NR4A1 and exhibited NR4A1 antagonist activities in rhabdomyosarcoma cells and inhibited tumor growth in an athymic mouse xenograft model [33]. Here, NR4A1 is linked to rhabdomyosarcoma.