NR4A3 and leukemia: In contrast, based on the results of NRA41 and NR4A3 knockout studies on mice, it was shown that the dual knockdown of both NR4A1 and NR4A3 in mice resulted in the development of leukemia, and NR4A1 and NR4A3 exhibited tumor suppressor-like activities in most blood-derived tumors [41,42].