ADAM17 and neuroblastoma: To strengthen the analysis of our bioinformatic approach demonstrating the down-regulation of genes encoding γ-secretase and ADAM17 in the 39-human NB-cell-line dataset (Figure 3A and Figure S4), we sought to evaluate the baseline expression levels of genes encoding γ-secretase and ADAM17 in a set of human NB cell lines representative of MYCN-amplified and non-MYCN-amplified NB.