The transcript levels of genes encoding the γ-secretase complex subunits and ADAM17 were found to be significantly lower in the MYCN-amplified NB cell lines IMR32, KELLY, SK-N-BE(2), and CHP212 compared with the non-MYCN-amplified NB cell lines SK-N-FI, SH-SY5Y, and SK-N-AS (Figure 3B). The gene discussed is MYCN; the disease is neuroblastoma.