PDE7A and myeloid sarcoma: Moreover, PDE8 inhibition with s.c. 2.5 mg/kg of PF-04957325 could not reduce T-cell proliferation in an allergic airway disease mouse model but could regulate T-cell effector interactions with the endothelial cells (for a comprehensive review of the effect of PDE7 and PDE8 inhibition on lymphocytes in MS, please read the review of Schepers et al.)[81,104].