Interestingly, lipid raft disruption and EGF stimuli increased AQP3 expression in MCF7 and SkBr3 cell lines, which can further support malignant transformation, as shown in lung adenocarcinoma, where AQP3 facilitated H2O2 uptake which further oxidized and inactivated PTEN (phosphatase and tensin homolog), inhibiting autophagy and stimulating proliferation of lung adenocarcinoma cells [33]. This evidence concerns the gene PTEN and lung adenocarcinoma.