We analyzed the expression of AQP3, PI3K, and pAkt/Akt as a part of EGFR/PI3K/Akt pathway, as well as NRF2 in three cancer cell lines and nontumorigenic cell line in order to investigate the influence of lipid raft disruption and EGF treatment on these proteins (Figure 6). The gene discussed is AKT1; the disease is cancer.