Seventeen proteins had more than a 50% difference between subjects with dementia and controls, including VIM (2.2 fold increase), NTproBNP (2.2 fold increase), CHIT1 (2.2 fold increase), NEFL (1.7 fold increase), ENPP7 (1.6 fold decrease), and FCGR2A (1.5 fold decrease). The gene discussed is CHIT1; the disease is dementia.