Seventeen proteins had more than a 50% difference between subjects with dementia and controls, including VIM (2.2 fold increase), NTproBNP (2.2 fold increase), CHIT1 (2.2 fold increase), NEFL (1.7 fold increase), ENPP7 (1.6 fold decrease), and FCGR2A (1.5 fold decrease). This evidence concerns the gene NPPB and dementia.