Interestingly, the further examination of how these plasma proteins were dysregulated in relation to cognitive decline showed that the top six proteins correlated with the MoCA score (r2 < −0.45, p-value < 0.05), namely RSPO1, NEFL, IL17D, CCL28, WNT9A, and PGF, and they were dysregulated in those with more advanced dementia with severe cognitive deficits (MoCA score < 15). Here, RSPO1 is linked to Cognitive impairment.