For tumor-endothelial cell interactions, Gal3 expressed in endothelium can participate in the docking of cancer cells on capillary endothelium by specifically interacting with cancer cells-associated TF-disaccharide (TFD, Galβ1,3GalNAc) present in the core I structure of mucin-type O-linked glycan [106,107]. This evidence concerns the gene LGALS3 and cancer.