LGALS3 and Familial prostate cancer: The role of Gal3 in neo-angiogenesis has been corroborated, as the disruption of Gal3 expression impairs angiogenesis by reducing VEGF secretion from TGFβ1-induced macrophages [101], while overexpression of Gal3 in a Gal3-deficient prostate cancer cell line, LNCaP, induced in vivo tumor growth and angiogenesis [102].