LGALS3 and Familial prostate cancer: The role of Gal3 in prostate cancer metastasis has been demonstrated, as the metastasis was blocked or prevented in an experimental metastasis assay in nude mice using Gal3 knockout PC-3 prostate cancer cells [37] and in a transgenic mouse model of aggressive metastatic prostate cancer treated with our proprietary Gal3 inhibitor, GM101 (unpublished results).