AKAP1 coordinates the spatial organization and temporal regulation of cAMP and related signaling cascades in cardiac and vascular cells, contributing to cardiac physiology, including Ca2+ cycling, cardiac contractility, action potential duration, and to pathophysiological processes, such as arrhythmias, CM hypertrophy, heart failure, and hypoxia-adaptive responses [40,41,42]. This evidence concerns the gene AKAP1 and Arrhythmia.