Relevant signaling pathways in BC are phosphoinositide-3- kinase/Akt/mammalian target of rapamycin (PI3K/AKT/mTOR) and mitogen-associated protein kinase (MAPK)/RAS/RAF pathways stimulated by hormone receptors and HER2, which are also affected by the interplay of lncRNAs and miRNAs. This evidence concerns the gene RAF1 and breast cancer.