In 2010, Wang et al. [30] first identified the lncRNA-associated endogenous RNA (ceRNA) mechanism in liver cancer, where lncRNA HULC served as a sponge for miR-372, inhibited its activities, and consequently reduced the repression of PRKACB (pigmented spots, myxomas, pituitary adenomas), which in turn induced phosphorylation of CREB. The gene discussed is PRKACB; the disease is myxoma.