In BC cells, MALAT1 binds to miR-1, miR-124, and miR-448, acting as a sponge to downregulate CDC42, a member of the Rho-GTPase family, as well as upregulating the cyclin-dependent kinase 4 CDK4 expression, leading to BC cell cycle progression, cell migration, and invasion [150,151,152]. The gene discussed is CDK4; the disease is breast cancer.