In 2010, Wang et al. [30] first identified the lncRNA-associated endogenous RNA (ceRNA) mechanism in liver cancer, where lncRNA HULC served as a sponge for miR-372, inhibited its activities, and consequently reduced the repression of PRKACB (pigmented spots, myxomas, pituitary adenomas), which in turn induced phosphorylation of CREB. This evidence concerns the gene PRKACB and liver cancer.