In the spinal cord of Ptprz1-deficient C57BL/6 mice with experimental autoimmune encephalomyelitis, Tyr1105 phosphorylation in p190 Rho GAP was independent of Fyn, supporting the notion that p190 Rho GAP is a PTPRZ1 substrate [49,53]. Here, PTPRZ1 is linked to experimental autoimmune encephalomyelitis.