PTPRZ1 and glioblastoma: In a similar approach, a self-assembled hybrid micelle that can cross the blood–brain barrier, and simultaneously target M2-like tumor-associated macrophages by a specific peptide and GBM stem cells by an anti-PTPRZ1 antibody, was developed as a nanocarrier to deliver the chemotherapeutic agent doxorubicin to the GBM tissue.