In the spinal cord of Ptprz1-deficient C57BL/6 mice with experimental autoimmune encephalomyelitis, Tyr1105 phosphorylation in p190 Rho GAP was independent of Fyn, supporting the notion that p190 Rho GAP is a PTPRZ1 substrate [49,53]. The gene discussed is CNTNAP1; the disease is experimental autoimmune encephalomyelitis.