PTPRZ1 and experimental autoimmune encephalomyelitis: However, in the spinal cord of Ptprz1-deficient C57BL/6 mice with experimental autoimmune encephalomyelitis [49], and in mouse oligodendrocyte-lineage OL1 cells [50], it was shown that there were no significant differences in the tyrosine phosphorylation of Fyn related to PTPRZ1.