Overall, the key significantly upregulated genes based on FC values were Cyp2a5, Tgm1, and Lcn2 (2.4, 4.57, and 4.26 folds, respectively), whereas downregulated genes were Prl, Hcrt, and Pou4f2 (−4.35, −3.3, and −6.1 folds, respectively), at pre-, post-stroke day 1 and day 3, respectively (Figure 2B–D; Supplementary Table S1). This evidence concerns the gene POU4F2 and Stroke.