Considering all that was said above, the aim of this study was to evaluate the immunohistochemical pattern of histone H2A variant (H2AX, γH2AX, H2AXY142ph and H2AZ) expression in an experimental model of ischemia–reperfusion-induced acute kidney injury in spontaneously hypertensive rats (SHRs). Here, H2AX is linked to acute kidney injury.