INS and type 2 diabetes mellitus: Noteworthy, it was demonstrated that the phytochemicals naringin and its aglycone NAR, have potent anti-diabetic effects in nicotinamide/streptozotocin-induced type 2 diabetic rats via their insulin-improving action, which is mediated through the enhancement of insulin receptor (INSR) and glucose transporter type 4 (GLUT4) levels [7].