Association studies between single-nucleotide polymorphisms (SNPs) in mitotic phase-related genes and overall survivals of patients with non-small-cell lung cancer identified three independent SNPs in the PRIM2, CHEK1 and CDK6 genes, suggesting that these genetic variants are useful prognostic markers of the patients suffering non-small-cell lung cancer [20]. The gene discussed is PRIM2; the disease is non-small cell lung carcinoma.