In CTCL specifically, CXCR4 plays a role in cell migration and chemotaxis and may promote cutaneous homing of cells through interactions between CXCR4 on malignant lymphocytes and CXCL12 on fibroblasts and dermal stromal cells [30,31]. This evidence concerns the gene CXCR4 and primary cutaneous T-cell non-Hodgkin lymphoma.