Actually, a broad spectrum of causative agents is involved in the induction of glaucoma and retinal degeneration, including increased IOP, hypoxic insult, oxidative stress, excitotoxicity, activated Müller microglia-derived inflammatory cytokines, lack of neurotrophins such as brain-derived neurotrophic factor (BDNF), and so on [8]. The gene discussed is BDNF; the disease is retinal degeneration.