In a small cohort of 50 healthy control and 100 COVID-19 patients with severe or moderate disease, the expression levels for TLR2 and TLR4 mRNA were positively correlated with kidney and heart function biomarkers in serum [127], suggesting that the TLR2 and TLR4 sensors are possible targets to prevent the severity of COVID-19. The gene discussed is TLR4; the disease is COVID-19.