STUB1 and atherosclerosis: This idea is supported by experimental evidence in rodent models in which mutations in genes such as Dnmt3a, Tet2, or Jak2V617F (all being mutations associated with CHIP) have been associated with accelerated atherosclerosis, the upregulation of pro-inflammatory pathways, and increased activity of the AIP2 and NLRP inflammasomes [28,29,30].