The −675 [rs1799889] 4G>5G, 10692 [rs11178] T>C, and 12068 [rs1050955] G>A genotypes of PAI-1 were significantly associated with ischemic stroke risk, whereas the −844 [rs2227631] G>A, 43 [rs6092] G>A, 9785 [rs2227694] A>G, and 11053 [rs7242] T>G polymorphisms were not (Table 2). Here, SERPINE1 is linked to ischemic stroke.