Conversely, decreased risk of metabolic syndrome was associated with PAI-1 alleles ‘4G4G/GA’ (rs1799889/rs6092), ‘GG/TC’ (rs6092/rs11178), ‘TC/TG’ (rs11178/rs7242), and ‘CC/TT’ (rs11178/rs7242) (Table 5). Here, SERPINE1 is linked to metabolic syndrome.