Another study identified six risk factors for metabolic syndrome including HTN, DM, hyperlipidemia, BMI ≥ 25 kg/m2, TG ≥ 150 mg/dL, and HDL < 40 mg/dL (male) or <50 mg/dL (female), which, combined with the PAI-1 −675 4G5G + 5G5G genotype, conferred a significantly increased AOR of metabolic syndrome (AOR = 2.780, 3.266, 1.779, 4.050, 1.714, and 6.781, respectively) relative to the PAI-1−675 4G4G genotype without these six predisposing risk factors [61]. This evidence concerns the gene SERPINE1 and hypertensive disorder.