SERPINE1 and stroke disorder: In particular, a reduced risk of metabolic syndrome and stroke is associated with PAI-1 SNPs in the promoter region, −844G>A, −6754G>5G, exon region (43G>A), and the 3′-UTR region SNP combination A-4G-A-T (MetS; OR: 0.073, FDR-p: 0.006) (stroke; OR: 0.141, FDR-p: 0.001).