PAI-1 −675 4G5G + 5G5G with HTN was two-fold more likely to increase ischemic stroke than the 4G4G genotype without HTN and was three-fold more likely to increase ischemic stroke risk in patients with a folate level ≤ 3.57 nmol/L (Figure 2). This evidence concerns the gene SERPINE1 and hypertensive disorder.