Interestingly, the infusion of exogenous ELA normalizes hypertension and proteinuria in ELA-deficient pregnant mice [24], suggesting that circulating ELA participates in maternal cardiovascular and renal adaptations to pregnancy independently of other well-known PE angiogenic factors (soluble fms-like tyrosine kinase-1 (sFlt-1)/placental growth factor [sFlt1/PlGF]) [24]. This evidence concerns the gene PGF and hypertensive disorder.