Similarly, the molecular profile in AD conducted on whole skin biopsies revealed the under-expression of epidermal differentiation complex (EDC) (e.g., FLG, LOC, S100A7/8/9, PI3, SPRR1A, and CLDNs) lymphoid tissue homeostatic systems (e.g., CCL19, CCL21, and CCR7) [84]. This evidence concerns the gene CCR7 and Alzheimer disease.