Even though we found potentially interesting associations between ten SNPs within the CAMK2D, CASP8, CFLAR, CXXC1, GPR37, IRF8, LEF1, MYNN, PRKD2, and TERC loci and the OS of CLL patients, none of these associations remained significant after correction for multiple testing. The gene discussed is LEF1; the disease is B-cell chronic lymphocytic leukemia.