As shown in Figure 1 and Supplementary Figure S1, co-cultures established with mDCs from HCs (Figure 1A) and IFNb-treated MS patients (Figure 1B), after they had been pretreated with IL-27 or IL-27/LPS, exhibited significantly less T cell proliferation (approximately 30–40% less proliferation) than the co-cultures that received the mDCs pretreated with media or LPS alone. Here, IFNB1 is linked to myeloid sarcoma.