In comparing the responses of HC- vs. untreated MS-derived mDCs to treatment with IL-27/LPS, the patient mDCs expressed significantly more STAT1 (LPS+IL-27 p = 0.04) and STAT3 (LPS+IL-27 p = 0.02) than the similarly treated HC mDCs. The gene discussed is STAT3; the disease is myeloid sarcoma.