In the monogenic form of PD, the two genes that contribute to the autosomal recessive form of the disease are PARK2 (encoding the Parkin protein) and PARK6 (encoding the PINK1 protein), which encode Parkin and PINK1, respectively, both of which play important roles in PINK1/Parkin-mediated mitophagy. Here, PRKN is linked to Parkinson disease.