Aerobic exercise increased autophagy in the striatum of PD rats, promoted the expression of autophagy markers Beclin1 and LC3 II/I, and increased the expression of lysosomal degradation-related molecules such as lysosome-associated membrane protein 2 (LAMP2) and cathepsin L. Regular aerobic exercise affects and regulates the homeostasis of apoptosis and autophagy in the striatum and alleviates the neurodegenerative process of PD [116]. The gene discussed is CTSL; the disease is Parkinson disease.