Additional evidence supporting the possible role of dysregulated mitophagy in neurodegeneration includes the observation that two cryptic PD genes and two LC3-interacting region (LIR) motif proteins associated with amyotrophic lateral sclerosis overlapping with frontotemporal dementia (ALS/FTD) are involved in the ubiquitin-mediated mitophagy pathway [40]. This evidence concerns the gene MAP1LC3A and amyotrophic lateral sclerosis.