In the PINK1 model of PD, ginsenoside proteins can exert neuroprotective effects by inducing the up-regulation of Hsp60, mitochondrial Hsp70 (mtHsp70), and CG5045 (a putative drosophila melanogaster protease that is 77% identical to worm CLpP)—which are key markers of UPRmt—in order to protect the mitochondria from PD-related OS [31]. Here, CLPP is linked to Parkinson disease.