ChIP-seq studies performed in mouse or human, liver, kidney, macrophages or cancer cell lines confirmed that ERRα can bind to promoters for OXPHOS (SDHD and SUCLA2), TCA (FASN), glycolysis/gluconeogenesis and lipid metabolism genes (GPAM and ELOVL6) [37,45,46,47,48]. This evidence concerns the gene ESRRA and cancer.