Anti-ERRα immunoprecipitation of MDA-MB-435 breast cancer cellular lysates treated with the iron chelator dipyridyl (DP) to stabilize endogenous HIF-1α, showed that all three ERRs associate to HIFα/β heterodimers both in vitro and in vivo, and this was abolished in ERRα mutants or with ERRα inhibitors [86]. Here, ESRRA is linked to breast carcinoma.