TF and COVID-19: Several mechanisms for thrombosis underlying the worsening of the condition of COVID-19 patients, such as old age, long time-bed rest and comorbidities [23,28], inflammation and cytokine storms [12], vascular endothelial injuries [74], primary pulmonary thrombosis [75], hypoventilation, a hypercoagulable state (including activation of the TF pathway) [74], neutrophil extracellular traps (NETs) [76], hypofibrinolysis [66] and platelet activation [60], have been proposed.