EP300 and cancer: For instance, BPA treatment of human breast cancer cells (MCF7) resulted in increased histone acetylation and H3K4 trimethylation through enrichment of the mixed-lineage leukemia family of histone methyltransferases (MLL2 and MLL3) and CREB-binding protein and p300 (CBP/p300; paralogous lysine acetyltransferases) at the promoter of HOXC6, HOXB9, and the enhancer of Zeste homolog 2 (EZH2) that are involved in breast cancer and other types of cancer [222,223,227].