KCNN4 and B-cell chronic lymphocytic leukemia: Also in chronic lymphocytic leukemia (CLL) Kv1.3 and KCa3.1 channels are highly expressed both in the plasma and mitochondrial membranes, and inhibiting mitoKv1.3 with PAPTP induces in vitro death of CLL cells, while inhibition of KCa3.1 with TRAM-34 decreases their proliferation.