Considering the altered glycome in cancer, it affects—globally—the biophysical properties of membranes [28] (thus, it indirectly influences the potassium channels’ activity via protein–lipid and protein–protein interactions [29,30]) and—locally—the glycosylation of the structure of the channels, which predefines their functionality [31,32,33,34,35]. This evidence concerns the gene KCNA3 and cancer.