Compared with the control group, an increased frequency of the pathogenic CFTR variant p.Phe508del was found in individuals with colorectal cancer (OR 1.17 (95% CI 1.02–1.32, p = 0.02)), gallbladder and biliary tract cancer (OR 1.92 (95% CI 1.20–2.91, p = 0.004)), thyroid cancer (OR 1.47 (95% CI 0.99–2.08, p = 0.04)) and non-Hodgkin’s lymphoma (OR 1.32 (95% CI 1.04–1.65, p = 0.02)). Here, CFTR is linked to thyroid cancer.