In particular, samples from ischemic stroke patients showed an increase in circulating CD106+ (+83.4%), CD31+ (+3.1%), CD171+ (+5.1%), Ephrin B+ (+21.5%) and CD11b+ (+21.8%) EVs, whereas we observed a decrease in the circulating IB4+ (−6.6%) and Klotho+ (−10.7%) compared to control subjects. This evidence concerns the gene L1CAM and ischemic stroke.