E-cadherin RIP (serum s-E-cad) is associated with various cancers [70] and E-cadherin depletion is correlated with pepsin presence in the larynx of LPR patients and observed in GERD/laryngopharyngeal reflux-attributed metaplasia and cancer and other aerodigestive conditions associated with impaired barrier integrity [73,74,75,76,77]. The gene discussed is CDH1; the disease is Laryngopharyngeal Reflux.