CDH1 and gastroesophageal reflux disease: The protective benefits of alginate against E-cadherin RIP and MMP dysregulation, which are in turn associated with GERD severity and carcinogenesis, are particularly intriguing given that the current mainstay treatment for severe GERD, PPIs, have failed to demonstrate chemopreventive benefit or stem the rising incidence of EAC despite their widespread use.