The results of the animal experiments showed that PB2 significantly decreased the levels of various inflammatory cytokines, such as IL-1β, GM-CSF, IFN-γ, and TNF-α in the blood serum, and IL-1β, IL-5, IL-6, GM-CSF, IFN-γ and TNF-α in the lung tissue of the ALI group. This evidence concerns the gene IL1B and acute respiratory distress syndrome.