NOS3 and myocardial ischemia: It is interesting to notice that in our population, the presence of rs5215_G/G of KCNJ11 or rs1799983_T/T of NOS3 alone did not reach a significant protective role, while the association of these two SNPs significantly increased the probability of being healthy, thus representing a protective factor against IHD (OR: 0.185; 95%CI: 0.440–0.770; p = 0.02), regardless of CV risk factors.