However, we speculate that, beyond the individual role of each genetic variant, the co-presence of the two polymorphisms may cause a mutual, positive influence between eNOS and the KATP channel, which may promote a protective vascular effect, preserving coronary circulation, both in the epicardial district and microcirculation, from atherosclerotic damage and vasomotor tone impairment, and reducing the risk of developing IHD. The gene discussed is NOS3; the disease is myocardial ischemia.