In the multivariable analysis, the co-presence of the SNPs rs5215_G/G and rs1799983_T/T of KCNJ11 and NOS3 respectively was confirmed to represent an independent protective factor against IHD (OR: 0.185; 95%CI: 0.440–0.770; p = 0.020). This evidence concerns the gene KCNJ11 and myocardial ischemia.