To date, such molecular pathways are known that regulate the expression and activity of NAMPT in cancers, such as c-MYC/NAMPT/SIRT1, HMGA1/NAMPT/NAD+, FOXO1/NAMPT, NAMPT/miRNA, SIRT6/SIRT1/NAMPT, C/EBPβ/NAMPT (Table 1). This evidence concerns the gene SIRT6 and cancer.