It was discovered through research into the impact of miR-224 on the growth of non-small cell lung cancer induced by cancer-associated fibroblast (NSCLC) that overexpression of SIRT3 can suppress miR-224 by activating AMPK and deactivating mTOR/HIF-1α [144]. The gene discussed is SIRT3; the disease is non-small cell lung carcinoma.