In this study, we focused on the effect of iron deficiency anemia on the secreted cytokines (IL-6, IL-1β, LIF, TGF-β), chemokines (IL-8, FKN), and other regulatory proteins (bone morphogenic protein 2 (BMP2), activin, follistatin, PR, SOX-17, PTGER2, TIMP2) and the modifying effect of FKN on the expression of these proteins, which may improve endometrium receptivity. This evidence concerns the gene CXCL8 and anemia.