To further understand the pathological phenotype of R-Ras KO mice in OIR and its contribution to pathological leakage in OIR and human retinopathies, we have carried out a comprehensive proteomics analysis of normoxic and OIR retina in R-Ras KO and WT at various points along OIR using recently developed mass spectrometry technique, sequential window acquisition of all theoretical mass spectra (SWATH-MS). The gene discussed is RRAS; the disease is retinal disorder.