CXCL8 and melanoma: Thus, taking it all into account, IL-8 secretion was higher for resistant melanoma cell populations (21_TRAR, 21 DH, 28_TRAR, 28 DH, 29 DH) with a dedifferentiation phenotype (MITFlow/NGFRhigh) than the 29_TRAR cell population grown in the presence of trametinib (TRAR) exerting a differentiation phenotype (MITFhigh/NGFRlow).