The top-scoring genes altered in the four gene sets included many genes associated with cell apoptosis and DNA damage, such as GADD45A, DDIT3, BAX, CASP1, CASP8, ATM, and FANCD2 (Figure 7D), demonstrating that diminishment of RAD51 contributes to the tumor suppressive effect. The gene discussed is CASP1; the disease is neoplasm.