OGT and Hyperglycemia: Specifically, while STZ-induced hyperglycemia increased OGT and O-GlcNAc protein expression by 2-fold in smOGTWT mice (p < 0.0001 vs. non-hyperglycemic smOGTWT), SMC-specific lack of OGT decreased OGT expression and protein O-GlcNAcylation in smOGTKO mice (p < 0.0001 compared to smOGTWT), and this effect was observed both basally and in response to hyperglycemia.