YY1 and diabetes mellitus: We further posit that OGT-mediated O-GlcNAcylation of YY1 activates SRF-dependent pathways and binding partners advancing VSMC cell cycle progression, concomitant to O-GlcNAc modification of alternate transcriptional regulator(s) promoting VSMC-to-macrophage fate switch and inflammatory VSMC phenotype in diabetes.