AGR3 and AGR2 genes were found downregulated in Basal-Like Breast Cancer (BLBC) of ER-luminal breast cell lines (ER+, PR+ or - and HER2+ or -) and upregulated in non-BLBC cell lines, the latter was shown to have less recurrence and less metastatic progression [33]. This evidence concerns the gene ESR1 and basal-like breast carcinoma.