The combination of HSD and HTN downregulated SIK1 protein content to the CTRL levels [DOCA: 0.48 ± 0.05 a.u.; DOCA-Salt: 0.25 ± 0.03 a.u. (p = 0.0231); CTRL: 0.22 ± 0.04 a.u. (p = 0.9994)]. This evidence concerns the gene SIK1 and hypertensive disorder.