NGF and disorder of sexual differentiation: Following SCI, DSD-induced overdistention of the bladder promotes NGF synthesis in the bladder, which appears to increase the excitability of C-fiber bladder afferent pathways, resulting in neurogenic DO [13,15,16,17] because the capsaicin-induced desensitization of C-fiber afferents inhibits DO in SCI rats and mice without affecting voiding contractions [18,19].