The downregulation of miR-217 and miR-199a rebounded macrophage Sirt1 levels, and miRNA levels were negatively correlated with Sirt1 levels to achieve anti-inflammatory and antioxidant effects on sepsis-associated ALI in vivo and in vitro, Sirt1 inhibition eliminated the protective effect of miR-217 and miR-199a downregulation on ALI [118,119]. This evidence concerns the gene SIRT1 and acute respiratory distress syndrome.