For example, in induced pluripotent stem cells (iPSC) and prostate cancer cells, mesenchymal genes, such as ZEB1, ZEB2, CDH2, TWIST and SNAI1/2, are enriched with EZH2 binding, but not epithelial genes such as CDH1 or SNAI3. The gene discussed is SNAI3; the disease is Familial prostate cancer.