They found that mice overexpressing α2-NKA had decreased cardiac hypertrophy, both acute and long-term, after pressure overload, increased NKA activity, enhanced removal of Ca2+ from the cytosol via NCX1 without any change in intracellular Na+ level, decreased PLM expression and phosphorylation, and suggested protective effects [56]. This evidence concerns the gene TAC1 and cardiac hypertrophy.