Hence, the results of our two previous works [5,6] and the present work revealed that bacteria treatment in vitro and in vivo with AgNPs decreases the bacterial ability to develop resistance to drugs due to (1) a decrease of bacterial capacity to get rid of antibiotics, (2) a decrease in their ability to adhere to cells to start an infection, and (3) a decrease in bacteria anti-lysozyme activity, thereby increasing the activity of lysozyme, a natural “antibiotic” present in the living organisms. Here, LYZ is linked to infection.