TRIM28 and neoplasm: The remaining detected variants were also located in genes with functions related to tumor processes, including transcriptional regulation and interaction with the Trim28 protein (ZNF19) [61], regulation of p53 and apoptosis (USP40) [62], induction of the Ras-MAPkinase/ERK and Akt/PKB pathways (DGKQ) [63] and cell proliferation (COL4A4) [64].